Digoxin that was used effectively in heart failure, atrial fibrillation, in some arrhythmias and in coronary myocardial disease would in our view help the brain without depress the heart. By the way,digoxin treatment at low doses (< or = 0.125 mg/d) is likely to result in low serum concentrations of 0.5 - 09 ng/ml (40). Gheorghiade M et al, in a retrospective analysis of data from the DIG trial also have indicated a beneficial effect of digoxin on morbidity and no excess mortality in women at serum concentrations from 0.5 to 0.9 ng/ml, whereas serum concentrations > or =1.2 ng/ml seemed harmful (41)
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